Publications

Cefiderocol In vitro Activity Against Molecularly Characterized Pseudomonas aeruginosa and Acinetobacter baumannii-calcoaceticus Complex Clinical Isolates Causing Infection in United States Hospitals (2020–2021). IDWeek 2022. October 19-21, 2022. Washington DC.

Performance of the VITEK 2 Advanced Expert System (AES) as a Rapid Tool for Reporting Antimicrobial Susceptibility Testing (AST) in Enterobacterales. Lead author: C Carvalhaes presented at European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 23-26, 2022, Lisbon, Portugal
Poster #1139

Evaluation of Gepotidacin Activity when Combined with Select Antimicrobial Agents and Tested Against Bacterial Isolates Using Checkerboard Methodology. Lead author: SJR Arends presented at European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 23-26, 2022, Lisbon, Portugal
Poster #L0184

Extended-spectrum beta-lactamases: An update on their characteristics, epidemiology and detection. by Castanheira M, Simner PJ and Bradford PA publised in JAC Antimicrob. Resist. 2021; 3 (3): dlab092

Assessment of Resistance Development to KBP-7072 by Serial-Passage and Single-Step Mutational Selection. Lead author: MD Huband presented at ECCMID 2021, July 9-12, Virtual Conference
Poster #1499

Impact of EUCAST, CLSI and USCAST ceftaroline breakpoint changes on the susceptibility of methicillin-resistant Staphylococcus aureus isolates collected from US medical centres (2015-2018). by Sader HS and Jones RN. published in Clin. Microbiol. Infect. 2020; 26 (5): 658-659

Resistance Mechanisms Associated with Pleuromutilins among Gram-Positive Clinical Isolates from the Worldwide Surveillance Program for Lefamulin in 2018. Lead author: RE Mendes. This poster was originally intended for presentation at ECCMID 2020, which was canceled due to the COVID-19 pandemic. The corresponding accepted abstract can be found in the 30th ECCMID abstract book under abstract 1322.
Poster #P0962

Correlation between broth microdilution and disk diffusion results when testing ceftazidime-avibactam against a challenge collection of Enterobacterales: Results from a multi-laboratory study. by Sader HS, Rhomberg PR, Chandrasekaran S, Trejo M, Fedler KA, Boyken LD and Diekema DJ published in J. Clin. Microbiol., 2020; 58 (4): e01757

Evaluation of antimicrobial effects of a new polymyxin molecule (SPR741) when tested in combination with a series of beta-Lactam agents against a challenge set of Gram-negative pathogens. by Mendes RE, Rhomberg PR, Lister T, Cotroneo N, Rubio A and Flamm RK published in Microb. Drug Resist.: in press, 2020

The Infectious Diseases Society of America’s 10 x ’20 Initiative (10 new systemic antibacterial agents US Food and Drug Administration approved by 2020): Is 20 x ’20 a possibility? by Talbot GH, Jezek A, Murray BE, Jones RN, Ebright RH, Nau GJ, Rodvold KA, Newland JG, Boucher HW and Infectious Diseases Society of A. published in Clin. Infect. Dis. 2019; 69 (1): 1-11

Resistance to Oral Antibiotics among Urinary Tract Infection Isolates of Escherichia coli from the United States and Europe in 2017. Lead author: IA Critchley, presented at ID Week 2019, October 2-6, Washington, DC, USA
Poster #1465

Pharmacokinetic-Pharmacodynamic Target Attainment Analyses to Support Lefamulin Dose Justification and Susceptibility Breakpoint Determinations for Patients With Community-Acquired Bacterial Pneumonia. Lead author: SM Bhavnani, presented at ASM/ESCMID 2019, September 3-6, Boston, MA, USA
Poster #19

Comparison of MIC Results for Gepotidacin by Agar Dilution and Broth Microdilution Methods. Lead author: SJ Ryan Arends, presented at ID Week 2019, October 2-6, Washington, DC, USA
Poster #701

Determination of MIC quality control ranges for the novel gyrase inhibitor, zoliflodacin. by Miller A, Traczewski T, Huband M, Bradford P and Mueller J. published in J. Clin. Microbiol, 2019 57 (9): e00567

Correlation between Broth Microdilution and Disk Diffusion Results When Testing Ceftazidime-Avibactam against a Challenge Collection of Enterobacterales: Results from a Multi-Laboratory Study. Lead author: HS Sader, presented at ASM Microbe 2019, June 20-24, San Francisco, CA, USA
# Sunday-CPHM-866

Evaluation of the bactericidal activity of fosfomycin in combination with selected antimicrobial comparison agents when tested against gram-negative bacterial strains using time-kill curves. by Flamm RK, Rhomberg PR, Lindley JM, Sweeney K, Ellis-Grosse EJ and Shortridge D. published in Antimicrob. Agents Chemother. 2019; 63 (5): e02549

Cefepime-Enmetazobactam (formerly AAI101; 30/20 µg) and Cefepime (30 µg) Disk Diffusion Quality Control Ranges Using a CLSI M23 (2018) Multi-Laboratory Study Design. Lead author: MD Huband, presented at ECCMID 2019, April 13-16, Amsterdam, Netherlands
#P2778

Correlation between Broth Microdilution and Disk Diffusion Methods Results when Testing Ceftaroline against Methicillin-Resistant Staphylococcus aureus Using the 5-µg Ceftaroline Disk. Lead author: HS Sader, presented at ECCMID 2019, April 13-16, Amsterdam, Netherlands
#P2783

Synergistic Activity of Colistin and Zidovudine (AZT) Combinations against Colistin-Resistant Enterobacteriaceae. Lead author: LR Duncan, presented at ECCMID 2019, April 13-16, Amsterdam, Netherlands
#P2787

Spectrum of Activity of RX-P2382, a Novel Class of Bacterial Ribosome Inhibitor. Lead author: D Shortridge, presented at ESCMID/ASM Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance, September 4-7, 2018, Lisbon, Portugal
#46

Antimicrobial Activity Assessment of Tebipenem (SPR859) against an Isolate Collection Causing Urinary Tract Infections. Lead author: RE Mendes, presented at ASM Microbe 2018, June 7-11, Atlanta, GA, USA
# Sunday-560

Antimicrobial Activity of GT-1, a Novel Siderophore Cephalosprin, Tested against Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter spp. Isolates. Lead author: LR Duncan, presented at ASM Microbe 2018, June 7-11, Atlanta, GA, USA
# Sunday-577

A systematic approach to the selection of the appropriate avibactam concentration for use with ceftazidime in broth microdilution susceptibility testing. by Bradford PA, Huband MD and Stone GG published in Antimicrob. Agents Chemother.: in press, 2018.

Disk content assessment and proposed breakpoint interpretive criteria for cefepime in combination with AAI101. Lead author: MD Huband, presented at the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2018, April 21-24, Madrid, Spain
#P0157

Assessment of ceftazidime-avibactam 30/20 µg disk content versus MIC results when tested against Enterobacteriaceae and Pseudomonas aeruginosa. by Sader HS, Rhomberg PR, Huband MD, Critchley IA, Stone GG, Flamm RK and Jones RN published in J. Clin. Microbiol. 2018 in press

Dilution factor of quantitative bacterial cultures obtained by bronchoalveolar lavage in patients with ventilator-associated bacterial pneumonia: Implications for optimal antimicrobial therapy ventilator-associated bacterial pneumonia study group. by Drusano GL, Corrado ML, Girardi G, Ellis-Grosse EJ, Wunderink RG, Donnelly H, Leeper KV, Brown M, Malek T, Hite RD, Ferrari M, Djureinovic D, Kollef MH, Mayfield L, Doyle A, Chastre J, Combes A, Walsh TJ, Dorizas K, Alnuaimat H, Morgan BE, Rello J, Mazo Torre CA, Jones RN, Flamm RK, Woosley L, Ambrose PG, Bhavnani S, Rubino CM, Bulik CC, Louie A, Vicchiarelli M and Berman C published in Antimicrob. Agents Chemother. 2018; in press

Enhanced activity of cefepime-tazobactam (WCK 4282) against KPC-producing Enterobacteriaceae when tested in media supplemented with human serum or sodium chloride. by Castanheira M, Duncan LR, Rhomberg PR and Sader HS published in Diagn. Microbiol. Infect. Dis.2017; 89 (4): 305-309

Evaluation of vancomycin and daptomycin potency trends (MIC creep) against methicillin-resistant Staphylococcus aureus isolates collected in nine U.S. medical centers from 2002 to 2006. by Sader HS, Fey PD, Fish DN, Limaye AP, Pankey G, Rahal J, Rybak MJ, Snydman DR, Steed LL, Waites K and Jones RN published in Antimicrob. Agents Chemother. 2009; 53 (10): 4127-4132

Resurgence of Pseudomonas endocarditis in Detroit, 2006-2008. by Reyes MP, Ali A, Mendes RE and Biedenbach DJ published in Medicine (Baltimore) 2009; 88 (5): 294-301

Strategic design of an effective β-lactamase inhibitor: LN-1-255, a 6-alkylidene-2′-substituted penicillin sulfone. by Pattanaik P, Bethel CR, Hujer AM, Hujer KM, Distler AM, Taracila M, Anderson VE, Fritsche TR, Jones RN, Pagadala SR, van den Akker F, Buynak JD and Bonomo RA published in J. Biol. Chem. 2009; 284 (2): 945-953

Comparison of 2002-2006 OPTAMA programs for US hospitals: Focus on gram-negative resistance. by Crandon JL, Kuti JL, Jones RN and Nicolau DP published in Ann. Pharmacother. 2009; 43 (2): 220-227.

Treatment of severe infections in the era of high rates of antimicrobial resistance. by Sader HS and Gales AC published in Braz. J. Infect. Dis. 2008; 12 (Suppl 2): S1-S2

Pharmacodynamics of ceftazidime and meropenem in cerebrospinal fluid: results of population pharmacokinetic modelling and Monte Carlo simulation. by Lodise TP, Nau R, Kinzig M, Drusano GL, Jones RN and Sorgel F, published in J Antimicrob Chemother 2007; 60 (5): 1038-1044

Determination of disk diffusion and MIC quality control guidelines for high dose cefepime-tazobactam (WCK 4282), a novel antibacterial combination consisting of a beta-lactamase inhibitor and a fourth-generation cephalosporin. by Riedel S, Huband MD, Sader HS, Flamm RK and Jones RN published in J. Clin. Microbiol. 2017; 55 (10): 3130-3134.

Meropenem-vaborbactam tested against contemporary Gram-negative isolates collected worldwide during 2014, including carbapenem-resistant, KPC-producing, multidrug-resistant, and extensively drug-resistant Enterobacteriaceae. by Castanheira M, Huband MD, Mendes RE and Flamm RK published in Antimicrob. Agents Chemother. 2017; 61 (9): e00567

Cefiderocol MIC quality control ranges in iron-depleted cation-adjusted Mueller-Hinton broth using a CLSI M23-A4 multi-laboratory study design. by Huband MD, Ito A, Tsuji M, Sader HS, Fedler KA and Flamm RK published in Diagn. Microbiol. Infect. Dis. 2017; 88 (2): 198-200

Pseudomonas aeruginosa bacteremic patients exhibit nonprotective antibody titers against therapeutic antibody targets PcrV and Psl exopolysaccharide. by Thaden JT, Keller AE, Shire NJ, Camara MM, Otterson L, Huband M, Guenther CM, Zhao W, Warrener P, Stover CK, Fowler VG, Jr. and DiGiandomenico A published in J. Infect. Dis. 2016; 213 (4): 640-648

In vivo emergence of ceftaroline resistance during therapy for MRSA vertebral osteomyelitis. by Sanchez EH, Mendes RE, Sader HS and Allison GM published in J. Antimicrob. Chemother. 2016; 71 (6): 1736-1738

Ceftazidime-avibactam activity against aerobic Gram negative organisms isolated from intra-abdominal infections in United States hospitals, 2012-2014. by Sader HS, Castanheira M, Flamm RK, Huband MD and Jones RN published in Surg. Infect. (Larchmt). 2016; 17 (4): 473-478

Activities of tedizolid and linezolid determined by the reference broth microdilution method against 3,032 Gram-positive bacterial isolates collected in Asia-Pacific, Eastern Europe, and Latin American countries in 2014. by Pfaller MA, Flamm RK, Jones RN, Farrell DJ and Mendes RE published in Antimicrob. Agents. Chemother. 2016; 60 (9): 5393-5399

Pharmacokinetics-pharmacodynamics of tazobactam in combination with piperacillin in an in vitro infection model. by Nicasio AM, VanScoy BD, Mendes RE, Castanheira M, Bulik CC, Okusanya OO, Bhavnani SM, Forrest A, Jones RN, Friedrich LV, Steenbergen JN and Ambrose PG published in Antimicrob. Agents. Chemother. 2016; 60 (4): 2075-2080

Comparison of BD Max StaphSR and BD Max MRSAXT for screening of Staphylococcus aureus clinical isolates collected from hospitals in the United States. by Mendes RE, Watters AA, Rhomberg PR, Farrell DJ and Jones RN published in J. Clin. Microbiol. 2016; 54 (6): 1668-1669

Multicenter investigation of gepotidacin (GSK2140944) agar dilution quality control determinations for Neisseria gonorrhoeae ATCC 49226. by Jones RN, Fedler KA, Scangarella-Oman NE, Ross JE and Flamm RK published in Antimicrob. Agents Chemother. 2016; 60 (7): 4404-4406

Effect of the β-Lactamase inhibitor vaborbactam combined with meropenem against serine carbapenemase-producing Enterobacteriaceae. by Castanheira M, Rhomberg PR, Flamm RK and Jones RN published in Antimicrob. Agents. Chemother. 2016; 60 (9): 5454-5458

High rates of nonsusceptibility to ceftazidime-avibactam and identification of New Delhi metallo-β-lactamase production in Enterobacteriaceae bloodstream infections at a major cancer center. by Aitken SL, Tarrand JJ, Deshpande LM, Tverdek FP, Jones AL, Shelburne SA, Prince RA, Bhatti MM, Rolston KV, Jones RN, Castanheira M and Chemaly RF published in Clin. Infect. Dis. 2016; 63 (7): 954-958

Antimicrobial activities of ceftaroline and comparator agents against bacterial organisms causing bacteremia in patients with skin and skin structure infections in U.S. Medical Centers, 2008 to 2014. by Sader HS, Flamm RK, Mendes RE, Farrell DJ and Jones RN published in Antimicrob. Agents. Chemother. 2016; 60 (4): 2558-2563

Dalbavancin activity when tested against Streptococcus pneumoniae isolated in medical centers on six continents (2011-2014). by Jones RN, Schuchert JE and Mendes RE. published in Antimicrob. Agents. Chemother. 2016; 60 (6): 3419-3425

Reproducibility of dalbavancin MIC test results and an updated surrogate accuracy analysis of vancomycin MIC values to infer dalbavancin susceptibility (2014). by Jones RN, Rhomberg PR and Mendes RE. published in Diag. Microbio. Infect. Dis. 2016; 86 (2): 249-251

Activity of fusidic acid tested against staphylococci isolated from patients in United States medical centers during 2014. by Farrell DJ, Mendes RE, Castanheira M and Jones RN published in Antimicrob. Agents Chemother. 2016; 60 (6): 3827-3831

Activity of Solithromycin Against Pathogens Associated with CABP: Global Surveillance Results from 2014, Lead author: Farrell DJ, presented at 55th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17-21,2015, San Diego, CA