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2018-05-31T12:33:53-05:00
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6178.122 2708.667 l
6178.122 2724.497 l
6152.188 2724.497 l
6152.188 2731.447 l
6172.033 2731.447 l
6172.033 2746.575 l
6152.188 2746.575 l
6152.188 2753.522 l
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6178.122 2769.356 l
h
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0 g
26.7968061 0 0 -26.7968061 6155.4210916 2739.0108763 cm
BX /Sh9 sh EX Q
Q
q
6218.371 2769.311 m
6218.371 2756.5 l
6225.596 2734.797 l
6206.402 2769.311 l
6183.174 2769.311 l
6183.174 2708.622 l
6203.029 2708.622 l
6203.029 2736.95 l
6218.753 2708.622 l
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EMC
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(E. coli )Tj
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EMC
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<000B005100200015001E00030013001100190008000C>Tj
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( )Tj
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(and )Tj
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(K. pneumoniae )Tj
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EMC
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EMC
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(harbored )Tj
ET
EMC
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(Klebsiella pneumoniae)Tj
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(E. coli )Tj
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(\(Figure 2\) )Tj
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(K. pneumoniae )Tj
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(CTX-M)Tj
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EMC
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( genes belonging to )Tj
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EMC
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BT
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EMC
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[<00170024>55<0003004400510047000300170025000C>]TJ
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EMC
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q
1169.743 27.616 1126.257 1031.581 re
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Q
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S
Q
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Q
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S
Q
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Q
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Q
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S
Q
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S
Q
q 1 0 0 1 1907.0706 620.2497 cm
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6.13 0.183 l
4.786 -2.445 l
S
Q
q 1 0 0 1 1839.8242 399.0253 cm
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S
Q
q 1 0 0 1 1742.3582 516.5888 cm
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S
Q
q 1 0 0 1 1767.8003 583.0593 cm
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23.291 -20.066 l
S
Q
0 0 0 0 K
2.15 w
/GS0 gs
q 1 0 0 1 1818.3252 608.1433 cm
0 0 m
0 -8.6 l
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S
Q
0 0 0 1 K
1.075 w
/GS2 gs
q 1 0 0 1 1818.3252 608.1433 cm
0 0 m
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-416.352 -8.6 l
S
Q
q 1 0 0 1 1901.9957 622.7451 cm
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0 29.025 l
S
Q
q 1 0 0 1 1752.3912 477.8888 cm
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39.779 0 l
S
Q
q 1 0 0 1 1821.7454 612.2659 cm
0 0 m
0.701 -2.868 l
-6.936 -4.898 l
-7.635 -2.027 l
S
Q
BT
/T1_0 1 Tf
-0.055 Tw 17.2 0 0 17.2 1939.0424 935.0977 Tm
(Plasmid AmpC)Tj
0 Tw 17.1994 -0.1567 0.1567 17.1994 1779.4713 987.6809 Tm
(Carbapenemase)Tj
17.2 0 0 17.2 1765.2786 963.2386 Tm
(Unknown)Tj
-6.324 -50.188 Td
(ESBL)Tj
8.05 45.276 Td
(KPC \(0.6%\))Tj
6.687 -1.495 Td
(CMY)Tj
-0.37 -0.875 Td
(\(7.8%\))Tj
4.701 -0.365 Td
(DHA)Tj
-0.445 -0.875 Td
(\(0.3%\))Tj
-9.506 -37.094 Td
(CTX-M)Tj
-0.167 -0.875 Td
(\(87.6%\))Tj
-1.353 40.469 Td
(TEM)Tj
-2.714 -0.386 Td
(SHV)Tj
10.246 -31.771 Td
(Group 1)Tj
0.056 -1 Td
(\(60.5%\))Tj
-15.66 23.818 Td
(Group 9)Tj
0.056 -0.875 Td
(\(26.9%\))Tj
13.054 -0.575 Td
(cAmpC)Tj
0.167 -1 Td
(\(1.2%\))Tj
3.033 3.593 Td
(CTX-M-3)Tj
0.555 -0.875 Td
(\(0.6%\))Tj
2.151 -2.067 Td
(CTX-M-10)Tj
0.833 -0.875 Td
(\(0.3%\))Tj
-11.26 -10.604 Td
(CTX-M-55)Tj
0.833 -0.875 Td
(\(4.1%\))Tj
-0.448 -5 Td
(CTX-M-15)Tj
0.555 -0.875 Td
(\(55.5%\))Tj
-1.034 11.605 Td
(CTX-M-27)Tj
0.555 -0.875 Td
(\(17.3%\))Tj
-0.055 Tw 15.905 20.542 Td
(Chromosomal AmpC)Tj
0 Tw -17.98 -7.927 Td
(Group)Tj
0.695 -0.875 Td
(1/9)Tj
1.638 -13.439 Td
(CTX-M-14)Tj
0.833 -0.875 Td
(\(8.7%\))Tj
-35.177 4.052 Td
[(SHV)55(-12)]TJ
0.25 -0.875 Td
(\(0.3%\))Tj
4.881 3.302 Td
(CTX-M-64)Tj
0.833 -0.875 Td
(\(0.3%\))Tj
-6.547 0.875 Td
(CTX-M-24)Tj
0.833 -0.875 Td
(\(0.3%\))Tj
4.712 3.135 Td
(CTX-M-174)Tj
1.111 -0.875 Td
(\(0.3%\))Tj
ET
q 1 0 0 1 1401.9724 538.9767 cm
0 0 m
-209.283 0 l
-209.283 129.733 l
0 129.733 l
h
S
Q
BT
/T1_0 1 Tf
17.2 0 0 17.2 1202.8899 644.4803 Tm
(CTX-M-134)Tj
1.111 -0.875 Td
(\(0.3%\))Tj
5.408 -3.771 Td
(TEM-19)Tj
0.305 -0.875 Td
(\(0.3%\))Tj
ET
q 1 0 0 1 1994.4458 800.9263 cm
0 0 m
6.809 12.003 l
S
Q
0.6 0 0 0 k
1169.743 1020.484 1111.569 38.713 re
f
0 0 0 0 k
/GS0 gs
q 1 0 0 1 1193.5853 1050.5846 cm
0 0 m
0 -20.395 l
8.658 -10.198 l
h
f
Q
BT
/T1_1 1 Tf
21.5 0 0 21.5 1208.6931 1033.4139 Tm
(\037\036\035)Tj
/T1_0 1 Tf
( )Tj
/T1_2 1 Tf
(\037\036\035\034\033\032\031\035\034\031\030\027\035\026\025\031)Tj
ET
EMC
EMC
/Figure <>BDC
/PlacedPDF /MC2 BDC
q
2318.025 92.917 965.203 968.63 re
W n
1 0.6 0.1 0.1 k
q 1 0 0 1 2618.6697 896.788 cm
0 0 m
57.779 28.515 113.025 41.779 177.45 42.602 c
177.45 -348.266 l
h
f
Q
0 0 0 0 K
q 1 0 0 1 2618.6697 896.788 cm
0 0 m
57.779 28.515 113.025 41.779 177.45 42.602 c
177.45 -348.266 l
0 0 l
h
S
Q
0 0.65 1 0 k
q 1 0 0 1 2802.9355 103.797 cm
0 0 m
-155.03 -0.011 -296.515 84.951 -369.239 221.725 c
-477.386 425.124 -399.896 678.583 -196.499 786.732 c
-196.256 786.861 -196.007 786.992 -195.755 787.126 c
-3.132 409.083 l
371.492 608.274 l
421.301 511.102 431.15 400.371 399.154 295.713 c
366.53 188.996 294.296 101.372 195.768 48.983 c
135.504 16.942 67.809 0.002 0 0 c
f
Q
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(CTX-M)Tj
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(CTX-M-3)Tj
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[(SHV)55(-27)]TJ
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[(SHV)55(-5)]TJ
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[(SHV)55(-61)]TJ
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( )Tj
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(\(1A\) and )Tj
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(K. pneumoniae)Tj
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( )Tj
ET
EMC
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(\(1B\) causing UTI or BSI )Tj
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EMC
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BT
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(1246)Tj
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(1967)Tj
ET
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4950.248 1393.273 -17.002 17.002 re
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ET
0 0.65 1 0 k
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4108.422 1430.541 -17.002 17.002 re
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h
S
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BT
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[(1)74(155)]TJ
ET
0.265 0.415 0.16 0.065 k
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4108.422 1393.273 -17.002 17.002 re
f
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h
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BT
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[(CC1)74(1)]TJ
-0.232 -0.875 Td
(\(5.0%\))Tj
9.104 -4.312 Td
(CC307)Tj
-0.195 -0.875 Td
(\(15.0%\))Tj
6.098 -9.875 Td
(CC23)Tj
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(\(7.5%\))Tj
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(CC17)Tj
-0.195 -0.875 Td
(\(7.5%\))Tj
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(CC147)Tj
0.083 -0.875 Td
(\(5.7%\))Tj
8.695 -2.563 Td
(CC23)Tj
-0.195 -0.875 Td
(\(5.7%\))Tj
12.303 0.625 Td
(CC37)Tj
-0.195 -0.875 Td
(\(7.6%\))Tj
12.333 6.25 Td
(CC15)Tj
-0.195 -0.875 Td
(\(7.6%\))Tj
7.69 10.275 Td
(CC307)Tj
0.083 -0.875 Td
(\(7.6%\))Tj
-4.393 31 Td
[(CC1)74(1)]TJ
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(\(28.3%\))Tj
ET
EMC
EMC
/Span <>BDC
BT
/TT0 1 Tf
36 0 0 36 3906 2480.0938 Tm
(Figure 3 Distribution of clonal complexes among )Tj
ET
EMC
/Span <>BDC
BT
/TT4 1 Tf
36 0 0 36 4750.1191 2480.0938 Tm
(K. pneumoniae)Tj
ET
EMC
/Span <>BDC
BT
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36 0 0 36 5008.1484 2480.0938 Tm
( )Tj
ET
EMC
/Span <>BDC
BT
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36 0 0 36 3906 2436.0938 Tm
(isolates)Tj
ET
EMC
/Span <>BDC
BT
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36 0 0 36 4040.0684 2436.0938 Tm
( )Tj
ET
EMC
/Span <>BDC
BT
/TT0 1 Tf
36 0 0 36 4050.0703 2436.0938 Tm
(recovered from)Tj
ET
EMC
/Span <>BDC
BT
/TT2 1 Tf
36 0 0 36 4312.1777 2436.0938 Tm
( )Tj
ET
EMC
/Span <>BDC
BT
/TT0 1 Tf
36 0 0 36 4322.1797 2436.0938 Tm
(UTI \(outer circle\) and BSI \(inner circle\))Tj
ET
EMC
/Figure <>BDC
/PlacedPDF /MC5 BDC
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3318.316 133.517 883.668 925.167 re
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1 0.6 0.1 0.1 k
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h
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h
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S
Q
BT
0.672 0.59 0.566 0.703 k
/T1_8 1 Tf
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(Plasmid AmpC)Tj
2.157 1.958 Td
(Chromosomal AmpC)Tj
0 Tw 22.614 -48.448 Td
(ESBL)Tj
-9.675 4.031 Td
(CTX-M)Tj
6.22 7.708 Td
(Group 1)Tj
0.056 -1 Td
(\(75.0%\))Tj
-19.202 19.354 Td
(Group 9)Tj
0.056 -1 Td
(\(17.3%\))Tj
12.214 -13.105 Td
(CTX-M-15)Tj
0.555 -0.875 Td
(\(75.0%\))Tj
-3.74 19.219 Td
[(CMY)92(-42)]TJ
0.315 -0.875 Td
(\(1.9%\))Tj
3.067 -9.329 Td
(CTX-M-14)Tj
0.833 -0.875 Td
(\(1.9%\))Tj
-0.577 3.236 Td
(CTX-M-27)Tj
0.555 -0.875 Td
(\(15.4%\))Tj
-2.335 23.375 Td
(Unknown)Tj
0.852 -11.532 Td
(cAmpC)Tj
0.167 -1 Td
(\(3.9%\))Tj
ET
q 1 0 0 1 3666.9739 567.2902 cm
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54.646 0 l
S
Q
q 1 0 0 1 3680.9487 610.1107 cm
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44.972 0.178 l
S
Q
0.6 0 0 0 k
3318.316 1019.97 883.668 38.713 re
f
0 0 0 0 k
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8.658 -10.198 l
h
f
Q
BT
/T1_9 1 Tf
21.5 0 0 21.5 3357.2668 1032.9016 Tm
(\037\036\035)Tj
/T1_8 1 Tf
( )Tj
(BSI)Tj
ET
EMC
EMC
/Figure <>BDC
/PlacedPDF /MC6 BDC
q
4244.961 103.796 1199.002 955.961 re
W n
1 0.2 0 0 k
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h
f
Q
0 0 0 0 K
6.45 w
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h
S
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0 0.65 1 0 k
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h
f
Q
q 1 0 0 1 4685.7109 528.3536 cm
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h
S
Q
0 0.04 0.9 0 k
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h
f
Q
q 1 0 0 1 4685.7109 528.3536 cm
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h
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h
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f
Q
Q
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0 0 m
26.428 -50.703 l
S
Q
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0 0 m
0 39.201 l
S
Q
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0 0 m
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S
Q
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S
Q
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6.091 -0.17 l
S
Q
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S
Q
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0 0 m
25.936 -21.242 l
S
Q
0 0 0 0 K
2.15 w
/GS0 gs
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S
Q
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q 1 0 0 1 4672.2769 647.9503 cm
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S
Q
/GS2 gs
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-25.308 0.172 l
-25.129 -2.15 l
S
Q
BT
0 0 0 1 k
/T1_10 1 Tf
-0.055 Tw 17.2 0 0 17.2 4529.6196 962.5098 Tm
(Plasmid AmpC)Tj
2.588 1.582 Td
(Chromosomal AmpC)Tj
0 Tw 14.62 -51.071 Td
(ESBL)Tj
-9.675 4.031 Td
(CTX-M)Tj
11.902 13.27 Td
(Group 1)Tj
0 -1 TD
(\(67.6%\))Tj
-24.577 14.042 Td
(Group)Tj
1.112 -0.875 Td
(9)Tj
-1.472 -0.875 Td
(\(30.4%\))Tj
15.399 -3.027 Td
(CTX-M-3)Tj
0.555 -0.875 Td
(\(0.7%\))Tj
-0.673 -1.136 Td
(CTX-M-10)Tj
0.833 -0.875 Td
(\(0.7%\))Tj
-3.586 -6.441 Td
(CTX-M-15 )Tj
0.694 -0.875 Td
(\(66.2%\))Tj
0.27 34.125 Td
(TEM)Tj
-2.72 -27 Td
(CTX-M-14)Tj
0.833 -0.875 Td
(\(6.9%\))Tj
-1.583 4.021 Td
(CTX-M-27)Tj
0.555 -0.875 Td
(\(22.1%\))Tj
ET
0 0 0 0 k
/GS0 gs
5418.874 617.649 -299.934 101.059 re
f
2.15 w
/GS2 gs
q 1 0 0 1 5418.874 617.6489 cm
0 0 m
-299.934 0 l
-299.934 101.059 l
0 101.059 l
h
S
Q
BT
0 0 0 1 k
/T1_10 1 Tf
17.2 0 0 17.2 5128.7822 693.5686 Tm
(CTX-M-134)Tj
1.111 -0.875 Td
(\(0.7%\))Tj
5.139 0.937 Td
(CTX-M-174)Tj
1.111 -1 Td
(\(0.7%\))Tj
5.535 -0.501 Td
(DHA-1)Tj
0.028 -1 Td
(\(0.7%\))Tj
-11.979 -0.311 Td
(cAmpC)Tj
0.167 -1 Td
(\(0.7%\))Tj
5.945 1.062 Td
(TEM-19)Tj
0.305 -1 Td
(\(0.7%\))Tj
ET
0.6 0 0 0 k
4244.961 1021.045 1199.002 38.713 re
f
0 0 0 0 k
/GS0 gs
q 1 0 0 1 4268.8052 1051.146 cm
0 0 m
0 -20.395 l
8.658 -10.198 l
h
f
Q
BT
/T1_11 1 Tf
21.5 0 0 21.5 4283.9131 1033.974 Tm
(\037\036\035)Tj
/T1_10 1 Tf
( )Tj
(UTI)Tj
ET
EMC
EMC
/Span <>BDC
BT
0 0 0 1 k
/GS2 gs
/C2_0 1 Tf
36 0 0 36 3318.3162 1085.5154 Tm
<0029004C004A0058005500480003001700030027004C005600570055004C004500580057004C00520051000300520049000302150010004F00440046005700440050004400560048001000480051004600520047004C0051004A0003004A00480051004800560003004700480057004800460057004800470003004C00510003>Tj
ET
EMC
/Span <>BDC
BT
/TT4 1 Tf
36 0 0 36 4428.4629 1085.5154 Tm
(E. coli)Tj
ET
EMC
/Span <>BDC
BT
/TT2 1 Tf
36 0 0 36 4534.4941 1085.5154 Tm
( )Tj
ET
EMC
/Span <>BDC
BT
/TT0 1 Tf
36 0 0 36 4544.4961 1085.5154 Tm
(ST131)Tj
ET
EMC
/Span <>BDC
BT
/TT2 1 Tf
36 0 0 36 4650.5625 1085.5154 Tm
( )Tj
ET
EMC
/Span <>BDC
BT
/TT0 1 Tf
36 0 0 36 4660.5645 1085.5154 Tm
(causing UTI or BSI )Tj
ET
EMC
q
0 0 6480 3024 re
W n
0.96 0.663 0.146 0.017 K
93 w
/GS0 gs
q 1 0 0 1 5184 2459.5962 cm
0 0 m
1224 0 l
S
Q
q 1 0 0 1 5184 1731.5962 cm
0 0 m
1224 0 l
S
Q
q 1 0 0 1 5184 1489.5962 cm
0 0 m
1224 0 l
S
Q
/Span <>BDC
Q
BT
0 0 0 0 k
/GS0 gs
/TT0 1 Tf
60 0 0 60 5615.9854 2441.0962 Tm
(Conclusions)Tj
ET
EMC
/Span <>BDC
BT
0 0 0 1 k
/GS2 gs
/TT1 1 Tf
30 0 0 30 5202 2363.0962 Tm
()Tj
/Span<>> BDC
( )Tj
EMC
ET
EMC
/Span <>BDC
BT
/TT1 1 Tf
30 0 0 30 5238 2363.0962 Tm
(These data show the dissemination of )Tj
ET
EMC
/Span <>BDC
BT
/TT2 1 Tf
30 0 0 30 5749.9629 2363.0962 Tm
(E. coli)Tj
ET
EMC
/Span <>BDC
BT
/C2_1 1 Tf
30 0 0 30 5831.6572 2363.0962 Tm
<0003003600370014001600140003004C00560052004F00440057004800560003004C005100030057004B0048000300380051004C0057004800470003003600570044005700480056000F0003>Tj
ET
EMC
/Span <>BDC
BT
/C2_1 1 Tf
30 0 0 30 5238 2329.0962 Tm
<00550048004A004400550047004F0048005600560003005200490003004C00510049004800460057004C0052005100030056004C00570048001E00030057004B004800030053005200530058004F00440057004C0052005100030056005700550058004600570058005500480003005200490003>Tj
ET
EMC
/Span <>BDC
BT
/TT2 1 Tf
30 0 0 30 5958.4102 2329.0962 Tm
(K. pneumoniae )Tj
ET
EMC
/Span <>BDC
BT
/TT1 1 Tf
30 0 0 30 6168.5566 2329.0962 Tm
(was more )Tj
ET
EMC
/Span <>BDC
BT
/TT1 1 Tf
30 0 0 30 5238 2295.0962 Tm
(heterogeneous)Tj
ET
EMC
/Span <>BDC
BT
/TT1 1 Tf
30 0 0 30 5202 2249.0962 Tm
()Tj
/Span<>> BDC
( )Tj
EMC
ET
EMC
/Span <>BDC
BT
/C2_1 1 Tf
30 0 0 30 5238 2249.0962 Tm
<002C00510003004400470047004C0057004C00520051000F00030057004B00480003004700440057004400030046005200510049004C0055005000030057004B00480003004700520050004C005100440051004600480003005200490003004A005500520058005300030014000300260037003B00100030001000480051004600520047004C0051004A0003004A004800510048005600030044005000520051004A0003>Tj
ET
EMC
/Span <>BDC
BT
/TT1 1 Tf
30 0 0 30 5238 2215.0962 Tm
(ST131 )Tj
ET
EMC
/Span <>BDC
BT
/TT2 1 Tf
30 0 0 30 5334.7236 2215.0962 Tm
(E. coli)Tj
ET
EMC
/Span <>BDC
BT
/C2_1 1 Tf
30 0 0 30 5416.418 2215.0962 Tm
[<001E0003004B0052005A0048005900480055>54.7<000F00030057004B00480003004700440057004400030053005500480056004800510057004800470003004B004800550048000300500044005C000300560058004A004A00480056005700030048005000480055004A00480051004600480003005200490003004A00480051004800560003>]TJ
ET
EMC
/Span <>BDC
BT
/C2_1 1 Tf
30 0 0 30 5238 2181.0962 Tm
<00440056005600520046004C00440057004800470003005A004C0057004B000300260037003B001000300003005200490003004A00550052005800530003001C00030044005000520051004A000300380037002C0003004C00560052004F00440057004800560003>Tj
ET
EMC
/Span <>BDC
BT
/TT1 1 Tf
30 0 0 30 5202 2135.0962 Tm
()Tj
/Span<>> BDC
( )Tj
EMC
ET
EMC
/Span <>BDC
BT
/C2_1 1 Tf
30 0 0 30 5238 2135.0962 Tm
<0037004B004C005600030056005700580047005C00030053005500520059004C0047004800560003004400030045004800510046004B005000440055004E000300490052005500030057004B004800030047004C005600570055004C004500580057004C00520051000300520049000302150010004F004400460057004400500044005600480003004A0048005100480056000300440051004700030057004B00480003>Tj
ET
EMC
/Span <>BDC
BT
/TT1 1 Tf
30 0 0 30 5238 2101.0962 Tm
(population structures of the most common )Tj
ET
EMC
/Span <>BDC
BT
/TT2 1 Tf
30 0 0 30 5804.9385 2101.0962 Tm
(Enterobacteriaceae )Tj
ET
EMC
/Span <>BDC
BT
/TT1 1 Tf
30 0 0 30 6073.4443 2101.0962 Tm
(species responsible for )Tj
ET
EMC
/Span <>BDC
BT
/C2_1 1 Tf
30 0 0 30 5238 2067.0962 Tm
[<00250036002C0003004400510047000300380037002C0003004C00510003003800360003005000480047004C00460044004F000300460048005100570048005500560003004C005100030057004B0048000300360028003100370035>17.3<003C>18<0003003300550052004A005500440050>]TJ
ET
EMC
/Span <>BDC
BT
/TT1 1 Tf
-0.01 Tc 0.01 Tw 30 0 0 30 5202 2021.0962 Tm
()Tj
/Span<>> BDC
( )Tj
EMC
ET
EMC
/Span <>BDC
BT
/TT1 1 Tf
0 Tw 30 0 0 30 5238.2998 2021.0962 Tm
[(Coupling genome sequencing with powerful bioinformatic tools can be usef\
ul to help)-10.1( )]TJ
ET
EMC
/Span <>BDC
BT
/TT1 1 Tf
30 0 0 30 5238 1987.0962 Tm
(detect and monitor resistance genes and bacterial populations in surveil\
lance programs)Tj
ET
EMC
/Span <>BDC
BT
/TT1 1 Tf
0 Tc 30 0 0 30 5202 1941.0962 Tm
()Tj
/Span<>> BDC
( )Tj
EMC
ET
EMC
/Span <>BDC
BT
/C2_1 1 Tf
30 0 0 30 5238 1941.0962 Tm
<00290058005700580055004800030056005700580047004C0048005600030057004B004400570003004C00510046004F0058004700480003004C00560052004F00440057004800560003005500480046005200590048005500480047000300490055005200500003003800360003005000480047004C00460044004F000300460048005100570048005500560003004700580055004C0051004A000300500058004F0057004C0053004F00480003>Tj
ET
EMC
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