Publications

Tigecycline Activity Tested Against Rarely Recovered Gram-positive Species, Lead author: Sader HS, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Antimicrobial Activity of PTK 0796 Tested against Gram-positive Organisms Causing Bloodstream Infections in 2009, Lead author: Sader HS, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Activity of Ceftaroline/NXL104 Tested against Contemporary (2009) Clinical Isolates of Staphylococci and Streptococci Collected from USA Medical Centers, Lead author: Sader HS, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Antimicrobial Activity of Ceftazidime/NXL104 Tested Against Gram-Negative Organisms, Including Multidrug-Resistant Subsets, Causing Infections in USA and European Medical Centers, Lead author: Sader HS, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Antimicrobial Spectrum and Potency of Ceftaroline Combined With NXL104 When Tested Against Enterobacteriaceae Collected From USA Hospitals, Lead author: Sader HS, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Worldwide Summary of Doripenem Spectrum and Activity: Potencies against 128,444 Gram-Positive Pathogens, Lead author: Farrell DJ, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Antimicrobial Activity of a Novel Polymyxin Analog (CB-182,804) Tested against Clinical Strains of Gram-Negative Bacilli, including Colistin-Resistant Organisms, Lead author: Sader HS, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Potency and Spectrum of Activity of AN3365: A Novel Boron-Containing Protein Synthesis Inhibitor Tested against Enterobacteriaceae, Lead author: Mendes RE, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Potency and Spectrum of Activity of AN3365, a Novel Boron-containing Protein Synthesis Inhibitor, Tested against Non-fermentative Gram-negative Bacilli, Lead author: Biedenbach DJ, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Activity BC-3781, a Novel Pleuromutilin Compound, Tested against Clinical Isolates of MRSA, Including Molecularly Characterized Community-Acquired and Hospital-Associated Strains, Lead author: Sader HS, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Antimicrobial Activity of the Investigational Pleuromutilin BC-3781 against Organisms Responsible for Community-Acquired Respiratory Tract Infections (CA-RTI), Lead author: Sader HS, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

In Vitro Activity of MC-1: A New Gram-Negative Antimicrobial Agent, Lead author: Farrell DJ, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Quality Control (QC) Limits for Antifungal Disk Diffusion Susceptibility Testing of Filamentous Fungi (Moulds) to Itraconazole, Posaconazole, Voriconazole & Amphotericin B, Lead author: Espinel-Ingroff, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Pharmacokinetic-Pharmacodynamic (PK-PD) Target Attainment Analyses to Evaluate Susceptibility Breakpoints (SB) for Labeled Cefepime Dosing Regimens, Lead author: Van Wart, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Pharmacokinetic-Pharmacodynamic (PK-PD) Basis for CLSI Carbapenem (CARB) Susceptibility Breakpoint Changes, Lead author: Bhavnani SM, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Rare Occurrence of Retapamulin Resistance Mechanisms in Staphylococcus aureus Clinical Isolates: Report from the SENTRY Program, Lead author: Mendes RE, presented at 50th annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 12 – 15, 2010, Boston, MA

Activity of Ceftaroline/NXL104 and Comparator Agents Tested Against Enterobacteriaceae Strains Producing KPC Serine-Carbapenemases, Lead author: Castanheira M, presented at 110th annual American Society for Microbiology General Meeting (ASM), May 23 – 27, 2010, San Diego, CA

Fluoroquinolone-resistant (FQR) H. influenzae (HI) Continue to be Infrequently Isolated, Within Worldwide Surveillance Networks (1997-2008), Lead author: Biedenbach DJ, presented at 110th annual American Society for Microbiology General Meeting (ASM), May 23 – 27, 2010, San Diego, CA

Linezolid Experience and Accurate Determination of Resistance (LEADER) Program: United States (USA) Results for 2009, Lead author: Ross JE, presented at 110th annual American Society for Microbiology General Meeting (ASM), May 23 – 27, 2010, San Diego, CA

Prevalence and Antimicrobial Susceptibility Profile of ESBL- and KPC-producing Enterobacteriaceae in the United States (2003-2008), Lead author: Jones RN, presented at 110th annual American Society for Microbiology General Meeting (ASM), May 23 – 27, 2010, San Diego, CA

Assessment of NXL104 Disk Content to Be Used to Test Ceftaroline in Combination, Lead author: Sader HS, presented at 110th annual American Society for Microbiology General Meeting (ASM), May 23 – 27, 2010, San Diego, CA

Evaluation of the Effects of pH, Serum Protein Concentration, Media Supplements, Inoculum Size, Media Type, and Incubation Conditions on Activity of Ceftaroline Combined with NXL104, Lead author: Rhomberg PR, presented at 110th annual American Society for Microbiology General Meeting (ASM), May 23 – 27, 2010, San Diego, CA

A Multi-Site Study of the Sensititre® Susceptibility System Compared with the CLSI Microdilution Method using New CLSI Breakpoints for MIC Determination of Enterobacteriaceae vs. Cephems, Lead author: Holliday, presented at 110th annual American Society for Microbiology General Meeting (ASM), May 23 – 27, 2010, San Diego, CA

Design and Evaluation of a Novel Dual-target Real-time PCR Assay for Neisseria gonorrhoeae Detection in Clinical Specimens, Lead author: Rebbapragada, presented at 110th annual American Society for Microbiology General Meeting (ASM), May 23 – 27, 2010, San Diego, CA

Telavancin Activity against Gram-positive Bacteria Isolated from Respiratory Tract Specimens of Patients with Nosocomial Pneumonia (2007-2008), Lead author: Mendes RE, presented at American Thoracic Society (ATS), May 14 – 19, 2010, New Orleans, LA

Ceftaroline Activity Against Bacterial Isolates from Patients with Community-Acquired Respiratory Tract Infections from United States Medical Centers in 2009, Including Methicillin-Resistant Staphylococcus aureus, Lead author: Sader HS, presented at American Thoracic Society (ATS), May 14 – 19, 2010, New Orleans, LA

Antimicrobial Activity and Spectrum of the Novel Cephalosporin Ceftaroline Tested Against Bacterial Isolates Causing Skin and Skin Structure Infections in USA Medical Centers, Lead author: Farrell DJ, presented at 30th annual Surgical Infection Society (SIS), April 17 – 20, 2010, Las Vegas, NV

Ceftaroline Activity against Clinical Isolates of Staphylococcus aureus, Including Methicillin-Resistant Strains (MRSA), from United States Hospitals, Lead author: Sader HS, presented at 30th annual Surgical Infection Society (SIS), April 17 – 20, 2010, Las Vegas, NV

Report of linezolid resistance from the Zyvox® Annual Appraisal of Potency and Spectrum Programme (Europe, Latin America, Asia-Pacific), Lead author: Ross JE, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Antimicrobial activity of doripenem against clinical bacterial pathogens from Europe, 2009, Lead author: Farrell DJ, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Ceftobiprole activity when tested against clinical bacterial pathogens from Europe, 2009, Lead author: Farrell DJ, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

In vitro activity of ceftaroline tested against leading Gram-positive and -negative European bacterial pathogens collected in 2009, Lead author: Castanheira M, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Activity of ceftaroline against recent (2009) and multidrug-resistant Streptococcus pneumoniae isolates from Europe and the United States, Lead author: Farrell DJ, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Oritavancin activity against Gram-positive pathogens isolated from United States and European medical centres, 2008-2009, Lead author: Mendes RE, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Spectrum of activity of oritavancin and comparison agents tested against contemporary Staphylococcus aureus collected in European hospitals, Lead author: Mendes RE, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Tigecycline activity tested against infrequently recovered clinical species of non-enteric Gram-negative bacilli, Lead author: Mendes RE, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

CEM-101, a novel fluoroketolide, tested against European clinical isolates from 2009 (first-year surveillance results), Lead author: Castanheira M, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Expanded studies of CEM-101, a novel fluoroketolide, tested against invasive isolates of N. meningitidis,including fluoroquinolone-non-susceptible resistant strains, Lead author: Biedenbach DJ, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Antimicrobial activity of the investigational pleuromutilin compound BC-3781 against Gram-positive organisms commonly associated with cutaneous infections, Lead author: Sader HS, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Activity of BC-3205 when tested against Gram-positive organisms responsible from skin and skin structure infections, Lead author: Sader HS, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Disc diffusion and MIC quality control ranges for BC-3205, a novel pleuromutilin class antimicrobial, Lead author: Ross JE, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Correlation of in vitro susceptibility testing results for an investigational pleuromutilin (BC-3781) using MIC and disc diffusion methods against Gram-positive pathogens, Lead author: Biedenbach DJ, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Correlations of broth microdilution MIC and disc diffusion results for an investigational agent, BC-3205 among potentially indicated species, Lead author: Biedenbach DJ, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

CEM-102 (fusidic acid) in vitro activity and evaluation of molecular resistance mechanisms among European Gram-positive isolates, 2008-2009, Lead author: Castanheira M, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Antimicrobial activity of ceftaroline tested against Staphylococcus aureus from the United States and Europe, 2008-2009, Lead author: Sader HS, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Antimicrobial spectrum of activity of telavancin and comparator agents tested against methicillin-resistant Staphylococcus aureus recovered from United States and European hospitals over a 3-year sampling period (2007-2009), Lead author: Mendes RE, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Activity of ceftaroline against selected clinical isolates of Staphylococcus aureus from the Canadian Bacterial Sentinel Network, Lead author: Farrell DJ, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Spectrum of activity of oritavancin and comparator agents tested against subsets of vancomycin-resistant enterococci from the United States and Europe, Lead author: Mendes RE, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

Differences between adult and paediatric serotypes and activity of ceftaroline for recent US isolates of Streptococcus pneumoniae, Lead author: Jacobs, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria

16S rRNA methylase containing Enterobacteriaceae in the SENTRY Asia-Pacific region frequently harbour plasmid-mediated quinolone resistance and CTX-M types, Lead author: Bell JM, presented at 20th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 10 – 13, 2010, Vienna, Austria