Publications

KPI-10, a Novel Fluoroquinolone Tested Against Neisseria gonorrhoeae including Ciprofloxacin Non-Susceptible and Penicillin Non-Susceptible Strains, Lead author: Flamm R, presented at 52nd annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 9 – 12, 2012, San Francisco, CA

In Vitro Activity of KPI-10 Tested Against Pathogens Commonly Associated with Urinary Tract infections, Lead author: Flamm R, presented at 52nd annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 9 – 12, 2012, San Francisco, CA

Activity of RPX2003/RPX7009 (RPX3/9), a Carbapenem Combined with a Novel &#223-lactamase Inhibitor Tested Against Clinical Isolates Producing Defined Enzymes, Lead author: Castanheira M, presented at 52nd annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 9 – 12, 2012, San Francisco, CA

Pre-clinical Evaluation of a Carbapenem/ß-Lactamase Inhibitor Combination (RPX2003/RPX7009) Tested Against Serine-carbapenemase-producing Pathogens, Lead author: Castanheira M, presented at 52nd annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 9 – 12, 2012, San Francisco, CA

Activity of MK-3118, a New Oral Glucan Synthase Inhibitor, Tested Against Aspergillus spp. using Two Reference Broth Microdilution Methods, Lead author: Castanheira M, presented at 52nd annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 9 – 12, 2012, San Francisco, CA

New CLSI Clinical Breakpoints and Epidemiological Cutoff Values Applied to Characterize Resistance in the SENTRY Antifungal Surveillance Program (2010-2011), Lead author: Castanheira M, presented at 52nd annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 9 – 12, 2012, San Francisco, CA

Comparative Potencies of Contemporary Generic Vancomycin Lots; in-vitro Assay results from Nine Products and a Reference Reagent-Grade Sample, Lead author: Jones RN, presented at 112th annual American Society for Microbiology General Meeting (ASM), June 16 – 19, 2012, San Francisco, CA

Use of Check-points Microarray for Beta-lactamase (BL) Detection Among Enterobacteriaceae (ENT) Bacteremia Isolates from USA Hospitals, Lead author: Castanheira M, presented at 112th annual American Society for Microbiology General Meeting (ASM), June 16 – 19, 2012, San Francisco, CA

Antimicrobial activity of ceftaroline and comparator agents against contemporary (2010) Streptococcus pneumoniae isolates from Latin America, Lead author: Sader HS, presented at 112th annual American Society for Microbiology General Meeting (ASM), June 16 – 19, 2012, San Francisco, CA

Antimicrobial activity of ceftaroline and comparator agents tested against contemporary (2010) Staphylococcus aureus, including MRSA isolates, from Latin America, Lead author: Sader HS, presented at 112th annual American Society for Microbiology General Meeting (ASM), June 16 – 19, 2012, San Francisco, CA

Antimicrobial activity of ceftaroline/avibactam tested against clinical Enterobacteriaceae isolates carrying multiple &#223-lactamases from USA medical centers, Lead author: Sader HS, presented at 112th annual American Society for Microbiology General Meeting (ASM), June 16 – 19, 2012, San Francisco, CA

Interim Susceptibility Testing for Ceftaroline (CPT), a Novel MRSA-Active Cephalosporin: Selecting Potent Surrogate &#223-Lactam Markers to Predict CPT Activity against Clinically Indicated Species, Lead author: Jones RN, presented at 112th annual American Society for Microbiology General Meeting (ASM), June 16 – 19, 2012, San Francisco, CA

Candida famata as a Cause of Invasive Candidiasis: Misidentification in Two Global Surveillance Systems, Lead author: Castanheira M, presented at 112th annual American Society for Microbiology General Meeting (ASM), June 16 – 19, 2012, San Francisco, CA

Contemporary Potencies of Minocycline (MIN) and Tetracycline (TET) Tested Against Gram-positive Pathogens: SENTRY Program Results using CLSI and EUCAST Breakpoint Criteria, Lead author: Jones RN, presented at 112th annual American Society for Microbiology General Meeting (ASM), June 16 – 19, 2012, San Francisco, CA

Influence of Surfactant (Polysorbate-80) on Susceptibility Testing Results for the Polymyxins Using Broth Microdilution Methods, Lead author: Sader HS, presented at 112th annual American Society for Microbiology General Meeting (ASM), June 16 – 19, 2012, San Francisco, CA

Educational Susceptibility (S) Testing as a Critical Component of Laboratory Proficiency Programs: American Proficiency Institute (API) Results for 2007-2010, Lead author: Jones RN, presented at 112th annual American Society for Microbiology General Meeting (ASM), June 16 – 19, 2012, San Francisco, CA

Outbreak of KPC-2-producing Klebsiella pneumoniae isolates in two Texas hospitals: Report from the SENTRY Antimicrobial Surveillance Program, Lead author: Mendes RE, presented at 112th annual American Society for Microbiology General Meeting (ASM), June 16 – 19, 2012, San Francisco, CA

Antimicrobial Activity of the New Cephalosporin Ceftaroline Tested Against Bacterial Isolates FromSurgical Skin and Skin Structure Infections in USA Medical Centers (2008-2011), Lead author: Sader HS, presented at 32nd annual Surgical Infection Society (SIS), April 18 – 21, 2012, Dallas, Texas

Transferable Plasmid-Mediated Resistance to Linezolid Due to cfr in a Human Clinical Isolate of Enterococcus faecalis, Lead author: Diaz, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Macrolide and tetracycline resistance in Moraxella catarrhalis isolates from 2009-2011 is higher in the Asia Pacific Region than in other regions of the world, Lead author: Flamm R, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Report of linezolid resistance from the Zyvox® Annual Appraisal of Potency and Spectrum programme (Europe, Latin America, Asia Pacific), Lead author: Flamm R, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Antimicrobial susceptibility and species identification of Corynebacterium spp. strains collected in Europe and USA medical centres, 2006-2010, Lead author: Sader HS, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Frequency and antimicrobial resistance of Gram-negative bacilli isolated from Latin America hospitals: results from SENTRY Antimicrobial Surveillance programme, 2008-2010, Lead author: Gales AC, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Activity and spectrum of antimicrobial coverage against pathogens collected from patients with hospital-acquired and ventilated-associated bacterial pneumonia in USA medical centres, Lead author: Sader HS, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Resistance phenotypes observed from amongst Staphylococcus aureus and pneumococci isolated from USA paediatric patients during the 2009 AWARE surveillance programme, Lead author: Krause, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Vancomycin MICs compared between MRSA and MSSA in 9 countries, Lead author: Reynolds, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Retrospective search for NDM-1 reveals Indian origin of DIM-1 metallo-betalactamase, Lead author: Castanheira M, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Characterisation of two new variants of 16S rRNA methylase encoding genes, rmtB2 and rmtB3, Lead author: Castanheira M, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Genotypic and phenotypic characterisation of methicillin-resistant Staphylococcus aureus strains recovered from a phase IV clinical trial for linezolid versus vancomycin for the treatment of nosocomial pneumonia, Lead author: Mendes RE, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

More potency assay results for EX-USA generic piperacillin/tazobactam lots and initial meropenem generic lots marketed in the USA, Lead author: Jones RN, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Activity of JNJ-Q2, a new fluoroquinolone, tested against contemporary (2011) acute bacterial skin and skin-structure infection pathogens from Europe, Lead author: Farrell DJ, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Activity of ceftaroline/avibactam tested against multidrug-resistant Enterobacteriaceae and methicillin-resistant Staphylococcus aureus collected from USA hospitals in 2011, Lead author: Sader HS, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Antimicrobial spectrum and potency of ceftaroline/avibactam when tested against bacterial isolates from complicated urinary tract infections in the United States, Lead author: Sader HS, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Activity of the novel antimicrobial ceftolozane/tazobactam (CXA-201) tested against contemporary clinical strains from European hospitals, Lead author: Sader HS, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Antimicrobial activity of PTK 0796 (omadacycline) and comparator agents against contemporary pathogens commonly associated with community-acquired respiratory tract infections collected during 2011 from the European Union, Lead author: Flamm R, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Antimicrobial activity of PTK 0796 (omadacycline) tested against Gram-positive organisms isolated from European hospitals in 2011, Lead author: Sader HS, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

In vitro evaluation of antimicrobial spectrum and determination of optimal MIC test conditions for the novel protein epitope mimetics antibiotic POL7080, Lead author: Dale, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Spectrum and potency of ceftaroline against leading pathogens causing skin and skin-structure infections in Europe and South Africa, 2010, Lead author: Farrell DJ, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Ceftaroline activity against clinical isolates from United States hospitals: results from the 2011 Assessing Worldwide Antimicrobial Resistance Evaluation programme, Lead author: Sader HS, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Spectrum and potency of ceftaroline against leading pathogens causing community acquired respiratory tract infections in Europe and South Africa, 2010, Lead author: Farrell DJ, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Antimicrobial activity of ceftaroline and comparator agents against contemporary (2010) Streptococcus pneumoniae from Europe and South Africa, Lead author: Farrell DJ, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Characterisation of resistance mechanisms and epidemiology of Enterobacteriaceae collected during a phase II clinical trial for ceftazidime avibactam, Lead author: Mendes RE, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Prevalence of ESBL and carbapenemase-producing phenotypes of Enterobacteriaceae identified in the 2010 AWARE surveillance programme, Lead author: Krause, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Occurrence and genetic analysis of OXA-48-producing strains in European countries, 2007-2010, Lead author: Castanheira M, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Activity of ceftaroline tested against methicillin-resistant Staphylococcus aureus clones from Australia and New Zealand, 2010, Lead author: Bell JM, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Oritavancin activity tested against Staphylococcus aureus responsible for documented infections in European hospitals, Lead author: Mendes RE, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Update on daptomycin activity and spectrum tested against Gram-positive organisms collected in 2011 from European medical centres, Lead author: Sader HS, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Activity of JNJ-Q2 against Staphylococcus aureus isolated from patients with acute bacterial skin and skin structure infection obtained during a phase II clinical trial, Lead author: Farrell DJ, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Adjusting EUCAST zone diameter breakpoints for Haemophilus influenzae on the Mueller-Hinton Fastidious media, Lead author: Ahman, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK

Contemporary doxycyline and tetracycline susceptibility testing using CLSI and EUCAST criteria for Gram-positive pathogens: results from SENTRY programme, Lead author: Jones RN, presented at 22nd annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), March 31 – April 3, 2012, London, UK