Publications

Pharmacodynamics of beta-lactamase inhibition by NXL104 in combination with ceftaroline, examining organisms with multiple types of beta-lactamases. by Louie A, Castanheira M, Liu W, Grasso C, Jones RN, Williams G, Critchley I, Thye D, Brown D, Vanscoy B, Kulawy R and Drusano GL published in Antimicrob. Agents Chemother. 2012; 56 (1): 258-270

Synergistic activity of ceftobiprole and vancomycin in a rat model of infective endocarditis caused by methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus. by Fernandez J, Abbanat D, Shang W, He W, Amsler K, Hastings J, Queenan AM, Melton JL, Barron AM, Flamm RK and Lynch AS published in Antimicrob. Agents Chemother. 2012; 56 (3): 1476-1484

Expansion of clonal complex 258 KPC-2-producing Klebsiella pneumoniae in Latin American hospitals: Report of the SENTRY antimicrobial surveillance program. by Castanheira M, Costello AJ, Deshpande LM and Jones RN published in Antimicrob. Agents Chemother. 2012; 56 (3): 1668-1669

Evaluation of quinolone resistance-determining region mutations and efflux pump expression in Neisseria meningitidis resistant to fluoroquinolones. by Castanheira M, Deshpande LM, Jones RN and Farrell DJ published in Diagn. Microbiol. Infect. Dis. 2012; 72 (3): 263-266

Activities of E1210 and comparator agents tested by CLSI and EUCAST broth microdilution methods against Fusarium and Scedosporium species identified using molecular methods. by Castanheira M, Duncanson FP, Diekema DJ, Guarro J, Jones RN and Pfaller MA published in Antimicrob. Agents Chemother. 2012; 56 (1): 352-357

Antimicrobial activity of the investigational pleuromutilin compound BC-3781 tested against gram-positive organisms commonly associated with acute bacterial skin and skin structure infections. by Sader HS, Biedenbach DJ, Paukner S, Ivezic-Schoenfeld Z, Jones RN published in Antimicrob. Agents Chemother. 2012; 56 (3): 1619-1623

Molecular evaluation of mupirocin resistances among Staphylococcus aureus collect in United States (USA) during 2008-2010, Lead author: Castanheira M, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Trends in Klebsiella pneumoniae carbapenemase positive (KPC+) K. pneumoniae in USA Hospitals: Report from the 2007-2009 from the SENTRY Antimicrobial Surveillance Program, Lead author: Kaise, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Antimicrobial Activity of Ceftaroline Tested Against Bacteria Collected from Patients with Respiratory Tract Infections in the United States (2010), Lead author: Sader HS, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Do CLSI breakpoints Predict Presence of Klebsiella pneumoniae Carbapenamase (KPC) Gene among USA Enterobacteriaceae isolates?, Lead author: Kaise, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Eight broad spectrum &#223-lactam agents tested against a large collection of KPC-producing Enterobacteriaceae: Evaluation of current CLSI breakpoints, Lead author: Castanheira M, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Antimicrobial Activity of Ceftaroline/NXL104 Tested Against Contemporary (2010) Clinical Isolates from USA Medical Centers, Lead author: Sader HS, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Antimicrobial Activity and Spectrum of the Novel Cephalosporin Ceftaroline Tested Against Bacterial Isolates Causing Skin and Skin Structure Infections in USA Medical Centers, Lead author: Sader HS, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Activity of JNJ-Q2 and Comparators against Genetically Defined MRSA Clones, Lead author: Farrell DJ, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Evaluation of Occurrence and Resistance Mechanisms of Pleuromutilins in Staphylococcus aureus Clinical Isolates: Report from the SENTRY Antimicrobial Surveillance Program, Lead author: Mendes RE, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Activity of JNJ-Q2, a Novel Fluoroquinolone, Tested against Neisseria gonorrhoeae, Including Ciprofloxacin-Resistant Strains, Lead author: Farrell DJ, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Wild-Type MIC Distributions and Epidemiological Cutoff Values for Fluconazole, Posaconazole and Voriconazole versus Cryptococcus neoformans as Determined by 72 hour CLSI Broth Microdilution Method, Lead author: Pfaller MA, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Wild-Type (WT) MIC Distributions and Epidemiological Cutoff Values (ECVs) for Selected Triazole and Echinocandin Antifungal Agents for Six Uncommon Species of Candida as Determined by CLSI Broth Microdilution (BMD) Methods, Lead author: Pfaller MA, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Pharmacokinetic-Pharmacodynamic (PK-PD) Target Attainment Analyses to Evaluate Susceptibility Breakpoints for Cefepime in Renal Impairment, Lead author: Van Wart, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Pharmacokinetic/Pharmacodynamic (PK/PD) Evaluations in Support of In Vitro Interpretive Criteria for Fluoroquinolones Against Salmonella and Enterobacteriaceae, Lead author: Bhavnani SM, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Differential &#223-Lactam Susceptibility Between Hospital and Community-Associated Clonal Complexes of Methicillin-Resistant Staphylococcus aureus from Australia and New Zealand (2009-2010), Lead author: Bell JM, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Contemporary (2010) Diversity of β-lactamases among Enterobacteriaceae collected from bacteremias in USA hospitals: Report from the SENTRY Antimicrobial Surveillance Program, Lead author: Castanheira M, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Antimicrobial Activity of Ceftazidime/NXL104 (CAZ104) Tested Against Gram-Negative Organisms Causing Infections in Medical Centers from Europe, Latin America and the Asia-Pacific Region, Lead author: Sader HS, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Oritavancin Activity against Vancomycin-susceptible and Genetically Characterized Vancomycin-resistant Enterococci from Bacteremic Patients (2009 – 2010), Lead author: Mendes RE, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Activity of Ceftaroline Combined with NXL104 Tested Against Bacterial Isolates from Patients with Respiratory Tract Infections from United States Medical Centers, Lead author: Sader HS, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

In Vitro Activity of Ceftaroline Tested against Bacterial Pathogens Frequently Isolated in United States Medical Centers: Results from the AWARE Surveillance Program, Lead author: Sader HS, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Activity of JNJ-Q2, a New Fluoroquinolone, Tested Against Contemporary Pathogens Isolated from Patients with Acute Bacterial Skin and Skin Structure Infection (ABSSSI), Lead author: Farrell DJ, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Activity of JNJ-Q2, a New Fluoroquinolone, Tested Against Contemporary Pathogens Isolated from Patients with Community-Acquired Bacterial Pneumonia (CABP), Lead author: Farrell DJ, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Assessment of Oritavancin Activity Tested against Gram-positive Bacteria from USA and European Medical Centers over a Three-year Period (2008 – 2010), Lead author: Mendes RE, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Update on Telavancin Activity Tested Against a Global Collection of Gram-positive Pathogens (2010), Lead author: Mendes RE, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Antimicrobial Activity of BC-3781, an Investigational Pleuromutilin, Tested Against Organisms Isolated From Patients with Community-Acquired Respiratory Tract Infections, Lead author: Sader HS, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Analysis of the Molecular Epidemiology of Staphylococcus epidermidis Clinical Isolates from USA Hospitals, Lead author: Mendes RE, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Occurrence of NDM-1 and other carbapenemases among Acinetobacter spp. and Pseudomonas spp. Collected from India, Lead author: Castanheira M, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

A Multi-Site Evaluation to Determine the Performance of the Sensititre YeastOne Susceptibility System using the Sensititre Vizion Compared to a Mirror Read Method, Lead author: Holliday, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Potency of Dalbavancin Tested Against 37,258 Gram-positive Cutaneous Pathogens from USA Medical Centers (2006-2009), Lead author: Jones RN, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Antimicrobial Activity of Daptomycin in Comparison to Glycopeptides and Other Antimicrobials When Tested against Numerous Species of Coagulase-negative Staphylococcus (CoNS), Lead author: Sader HS, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

In Vitro Activity of Ceftazidime/NXL104 Against Pathogens Collected During a Phase II Complicated Urinary Tract infection (cUTI) Clinical Trial, Lead author: Sader HS, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Activity of AFN-1252, a FabI Inhibitor with Potent Activity against S. aureus and Coagulase-Negative Staphylococcus spp. (CoNS), Including Multidrug-Resistant Strains, Lead author: Biedenbach DJ, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Antimicrobial Activity of Four Oxazolidinone Investigational Compounds Tested against a Collection of Linezolid-non-susceptible Strains with Genetically Defined Resistance Mechanisms, Lead author: Sader HS, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

In vitro Activity of a Novel Broad-spectrum Antifungal Agent, E1210, and Comparators Tested against Candida spp., Lead author: Castanheira M, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Pre-clinical Development of Susceptibility Testing Methods for the Novel Antifungal E1210 Tested against Candida: Comparison of CLSI and EUCAST Methods, Lead author: Castanheira M, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

In vitro Activity of a Novel Broad-spectrum Antifungal, E1210, Tested against Aspergillus spp. By CLSI and EUCAST Broth Microdilution Methods, Lead author: Castanheira M, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Profile of Staphylococcus aureus Isolated from United States (USA) Pediatric Patients During the 2009 Ceftaroline AWARE Surveillance Program, Lead author: Krause, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Evaluation of Pneumococci Isolated from United States (USA) Pediatric Patients During the 2009 AWARE Program, Lead author: Krause, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Molecular Identification of Clinically Significant Yeasts and Moulds in a Global Antifungal Surveillance Program, Lead author: Castanheira M, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Declining MRSA and Fluoroquinolone Resistance Rates Among S. aureus (SA) in the USA: Report from the SENTRY Antimicrobial Surveillance Program (2000–2009), Lead author: Jones RN, presented at 111th annual American Society for Microbiology General Meeting (ASM), May 21 – 24, 2011, New Orleans, LA

Surveillance of Linezolid Activity against Staphylococci in the United States (USA 2010), Lead author: Ross JE, presented at 111th annual American Society for Microbiology General Meeting (ASM), May 21 – 24, 2011, New Orleans, LA

Analysis of Linezolid Resistance Mechanisms and Epidemiology of Cfr-producing Strains in the United States, Lead author: Mendes RE, presented at 111th annual American Society for Microbiology General Meeting (ASM), May 21 – 24, 2011, New Orleans, LA

In Vitro Activity Of Anidulafungin and Voriconazole, and Comparators Against Aspergillus spp. as Determined By CLSI And EUCAST Broth Microdilution Methods, Lead author: Pfaller MA, presented at 111th annual American Society for Microbiology General Meeting (ASM), May 21 – 24, 2011, New Orleans, LA

An Evaluation of the New Sensititre AIM Performance Compared to the Existing Sensititre Autoinoculator for MIC Determination, Lead author: Killian SB, presented at 111th annual American Society for Microbiology General Meeting (ASM), May 21 – 24, 2011, New Orleans, LA