Publications

Characterization of Methicillin-resistant Staphylococcus aureus Bloodstream Isolates Recovered from Patients Enrolled in a Randomized, Double-blind, Multi-center Study to Establish the Efficacy and Safety of Ceftobiprole for Treatment of Bacteremia, Including Infective Endocarditis.  Lead author: Rodrigo E. Mendes, presented at IDWeek 2023, Oct 11-15, 2023, Boston, Massachusetts.

Poster #2785

Development and validation of an internal bioinformatic pipeline for 16S rRNA amplicon sequencing.  Lead author: Timothy B. Doyle, presented at ASM Microbe 2023, June 15-19, Houston, TX, USA

Cefiderocol In Vitro Activity Against Molecularly Characterized Acinetobacter baumannii-calcoaceticus complex and Pseudomonas aeruginosa Clinical Isolates Causing Infection in Europe and Adjacent Regions (2020–2021). Lead author: Rodrigo Mendes. ECCMID 2023, April 15-18, Copenhagen.

Comparison of In Vitro Activity of Cefiderocol and Comparator Agents Against Molecularly Characterized Carbapenem-resistant Enterobacterales Clinical Isolates Causing Infections in Europe and Surrounding Regions (2020–2021). Lead author: Dee Shortridge, ECCMID 23, April 15-18, Copenhagen.

Enterobacter hormaechei Carrying blaNDM Predominates Among Carbapenem-resistant Enterobacter spp. Collected During the SENTRY Antimicrobial Surveillance Program (2016–2021). Lead author: Hank Kimbrough.

Recent Increase in Fluconazole-Nonsusceptible Candida parapsilosis in a Global Surveillance with the Expansion of the Erg11 Y132F genotype and a Rapid Detection Method to Detect This Alteration. Lead Author: Mariana Castanheira, ECCMID 2023, April 15-18, Copenhagen.

Contemporary molecular epidemiology of Escherichia coli causing urinary tract infections in the United States and in vitro activity of tebipenem and comparators against various genetic subsets (2018-2020) by RE Mendes, SJ Ryan Arends, JM Streit, I Critchley, N Cotroneo, and M Castanheira in Microbiol Spectrum 2023; 11(1), 2057-22.

Trends of β-Lactamase Occurrence Among Escherichia coli and Klebsiella pneumoniae in United States Hospitals During a 5-Year Period and Activity of Antimicrobial Agents Against Isolates Stratified by β-Lactamase Type by M Castanheira, JH Kimbrough, S DeVries, RE Mendes, and HS Sader in Open Forum Infect Dis 10(2): 2023, ofad038.

The plethora of resistance mechanisms in Pseudomonas aeruginosa: transcriptome analysis reveals a potential role of lipopolysaccharide pathway proteins to novel β-lactam/ β-lactamase inhibitor combinations by M Castanheira, TB Doyle, CM Hubler, TD Collingsworth, S DeVries, RE Mendes in J Glob Antimicrob Resist 31 (2022), 72-79.

Induction of Resistance Against Antipseudomonal Agents: Comparison of Novel β-Lactam/β-Lactamase Inhibitor Combinations and Other
β-Lactam Agents. Lead author: Mariana Castanheira. IDWeek 2022. October 19-21. Washington DC.

In Vitro Activity of Cefiderocol and Comparator Agents Against Molecularly Characterized Clinical Isolates of Enterobacterales Causing Infections in United States Hospitals (2020–2021). Lead author: Rodrigo Mendes, IDWeek 2022, October 19-21, Washington DC.

Activity of Gepotidacin Tested Against Molecularly Characterized Escherichia coli Isolates Resistant to Commonly Used Oral Therapies for UTI in the US (2019–2020). Lead author: Rodrigo Mendes, IDWeek 2022, October 19-21, Washington DC.

Dual VIM-Producing Proteus mirabilis, Including a Novel VIM-75, Among Elderly Patients in a Medical Center from Hungary: Report from the 2020 SENTRY Antimicrobial Surveillance Program. Lead Author: Gauri Deshpande; Presented by: Mariana Castanheira, IDWeek 2022, October 19-21, Washington DC.

Antimicrobial Activity of Ceftibuten-Avibactam against a Global Collection of Enterobacterales from Patients with Complicated Urinary Tract Infections (2021). Lead author: Helio Sader, IDWeek 2022, October 19-21, Washington DC.

In Vitro Activity of Isavuconazole and Other Mould-Active Triazoles Against Aspergillus fumigatus With and Without cyp51 Alterations. Lead Author: Cecilia Carvalhaes, IDWeek 2022, October 19-21, Washington DC.

Prevalence, Phenotypic and Genotypic Characteristics, and Clinical Presentations of Staphylococcus argenteus Causing Bloodstream Infections in United States Hospitals. Lead author: Rodrigo Mendes, IDWeek 2022, October 19-21, Washington DC.

Prevalence of carbapenemase genes among carbapenem-nonsusceptible Enterobacterales collected in US hospitals in a five-year period and activity of ceftazidime/avibactam and comparator agents by Castanheira M, Deshpande LM, Mendes RE, Doyle TB, Sader HS in JAC-Antimicrob. Resist. 2022; 4(5): dlac098.

Azole resistance in Candida glabrata clinical isolates from global surveillance is associated with efflux overexpression by Castanheira M, Deshpande L, Davis A, Carvalhaes C, Pfaller M in J. Glob. Antimicrob. Resist. 29: 2022, 317-377.

Comparison of the VITEK2 Advanced Expert System phenotyping and genetic characterization of β-Lactamase genes for Enterobacterales isolates from North and Latin America. Lead author: CG Carvalhaes, presented at ASM Microbe 2022, June 9-13, Washington DC, USA

Poster #2427

Prediction of MIC values for four β-lactam agents for Escherichia coli and Klebsiella pneumoniae from a large surveillance program using genomic data and a machine learning model. Lead author: Cory Hubler, presented at ASM Microbe 2022, June 9-13, Washington DC

Detection of the carbapenem-hydrolyzing CTX-M-15 variant, CTX-M-33, among carbapenem-nonsusceptible Klebsiella pneumoniae isolates from Poland. Lead author Mariana Castanheira presented at ASM Microbe 2022, June 9-13, Washington DC

Cefiderocol In Vitro Activity against Molecularly Characterized Acinetobacter baumannii-calcoaceticus complex and Pseudomonas aeruginosa Clinical Isolates Causing Infection in Europe and Adjacent Regions (2020). Lead author: RE Mendes presented at European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 23-26, 2022, Lisbon, Portugal
Poster #1163

Comparison Analysis of In vitro Activity of Cefiderocol and Comparator Agents against Molecularly Characterized Carbapenem-resistant Enterobacterales Clinical Isolates Causing Infections in Europe and Surrounding Regions (2020). Lead author: RE Mendes presented at European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 23-26, 2022, Lisbon, Portugal
Poster #1158

Endemicity of Pseudomonas aeruginosa Producing IMP-18 and/or VIM-2 Metallo-β-Lactamases from the High-Risk Clone ST111 in Central America. Lead author: LM Deshpande presented at European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 23-26, 2022, Lisbon, Portgual
Poster #01136

Epidemiology of Escherichia coli Surveillance Isolates Causing Urinary Tract Infections in Europe and In Vitro Activity of Gepotidacin (2019-2020). Lead author: RE Mendes presented at European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 23-26, 2022, Lisbon, Portugal
Poster #01030

Increasing frequency of OXA-48-producing Enterobacterales worldwide and activity of ceftazidime/avibactam, meropenem/vaborbactam and comparators against these isolates. by Castanheira M, Doyle TB, Collingsworth TD, Sader HS and Mendes RE. published in J. Antimicrob. Chemother. 2021; 76 (12): 3125-3134

Epidemiology and Susceptibility Profiles of ST131-025b Escherichia coli Detected Among Cephalosporin- and/or Carbapenem-Resistant Isolates Collected in United States Hospitals. Lead author: M Castanheira presented at IDWeek 2021, September 29-October 3, Virtual Conference

In Vitro Analysis of AmpC β-lactamase Induction by Tebipenem in Enterobacterales and Pseudomonas aeruginosa. Lead author: RE Mendes presented at IDWeek 2021, September 29-October 3, Virtual Conference

Optimization of a 96-Well Plate Format Assay to Evaluate Concentration-Dependent Activity of a Monoclonal Antibody against the O Antigen 025b from ST131-H30 Escherichia coli. Lead author: J Lindley presented at IDWeek 2021, September 29-October 3, Virtual Conference

Molecular Epidemiology of Escherichia coli Causing Urinary Tract Infections in United States and In Vitro Activity of Tebipenem, Including against Strain Lineage and Resistant Subsets (2018-2020). Lead author: RE Mendes presented at IDWeek 2021, September 29-October 3, Virtual Conference

Epidemiology and Molecular Characterization of Linezolid Non-Susceptible Enterococcus spp. Clinical Isolates from the SENTRY Antimicrobial Surveillance Program (2017-2019). Lead author: CG Carvalhaes presented at ECCMID 2021, July 9-12, Virtual Conference
Poster #051

High Prevalence of Tetracycline Resistance Genes among Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis Clinical Isolates Causing Infections in Europe (2019). Lead author L Deshpande presented at ECCMID 2021, July 9-12, Virtual Conference
Poster #2235

Prevalence of CC131 and the Emergence of Other Sequence Types among Escherichia coli Isolates Causing Urinary Tract Infections from Asia-Pacific, Europe, and Latin America. Lead author: LM Deshpande presented at ECCMID 2021, July 9-12, Virtual Conference
Poster #422

In Vitro Activity of a Novel Aminomethylcycline Antibacterial (KBP-7072) against Clinical Isolates with Molecularly Characterized Tetracycline Resistance Mechanisms. Lead author: RE Mendes presented at ECCMID 2021, July 9-12, Virtual Conference
Poster #2189

Characterization of a vga gene variant recovered from a Staphylococcus saprophyticus causing a community-acquired urinary tract infection: Report from the SENTRY Antimicrobial Surveillance Program 2017. by Deshpande L, Cantrell L, Romero JR, Carvalhaes C and Sader HS. published in Diagn. Microbiol. Infect. Dis. 2021; 100 (4): 115398

Molecular characterization of baseline Enterobacterales and Pseudomonas aeruginosa isolates from a Phase 3 nosocomial pneumonia (ASPECT-NP) clinical trial. by Castanheira M, Johnson MG, Yu B, Huntington JA, Carmelitano P, Bruno C, Rhee EG and Motyl M. published in Antimicrob. Agents Chemother. 2021; 65 (3): e02461

Activity of Novel β-lactamase Inhibitor QPX7728 Combined with β-lactams Against ST258 Klebsiella pneumoniae and ST131 Escherichia coli isolates Producing β-lactamases. Lead author Mariana Castanheira. Presented at IDWeek 2020.

Presentation #166

In vitro activity analysis of a new generation polymyxin, SPR741, tested in combination with antimicrobial agents against a challenge set of Enterobacteriaceae, including molecularly characterized strains. by Mendes RE, Rhomberg PR, Lister T, Cotroneo N, Parr TR and Castanheira M. published in Antimicrob. Agents Chemother.: in press, 2020.

Analysis of a Worldwide Collection of Klebsiella pneumoniae CC258 with Reference to Carbapenemase Production Using the 1928 Core Genome (cg) Multilocus Sequence Type (MLST) Reveals Endemicity and the Global Dissemination of Clones. Lead author Lalitagauri Deshpande. Presented at IDWeek 2020.

Poster #831

Media for colistin susceptibility testing does not improve the detection of Klebsiella pneumoniae isolates carrying MgrB disruption and other mutation driven colistin resistance mechanisms. by Castanheira M, Doyle TB, Carvalhaes CG, Roth BM, Rhomberg PR and Mendes RE. published in Diagn. Microbiol. Infect. Dis. 2020; 98 (1): 115077

Plazomicin Activity against Enterobacterales Isolates Producing Extended-Spectrum β-Lactamases (ESBLs), Carbapenemases, and Aminoglycoside-Modifying Enzymes (AMEs) from United States (US) Hospitals. Lead Author: Mariana Castanheira. Presented at IDWeek 2020.

Poster #1278

Update on Prevalence of mcr-like Genes Among Enterobacterales in a Global Surveillance Program: Decline in Occurrence of mcr-1.1 and Emergence of mcr-9.1 and mcr-10.1. Lead Author: Lalitagauri Deshpande. Presented at IDWeek 2020.

Presentation Number: 166.

Analysis of a Worldwide Collection of Klebsiella pneumoniae CC258 with Reference to Carbapenemase Production Using the 1928 Core Genome (cg) Multilocus Sequence Type (MLST) Reveals Endemicity and the Global Dissemination of Clones. Lead author: LM Deshpande presented at IDWeek2020, October 21-22, Virtual Conference
Poster #831

Comparative Epidemiological Analysis of Serratia marcescens using PFGE and Whole Genome Sequence Methods. Lead author: LM Deshpande presented at ID Week 2020, October 21-22, Virtual Conference
Poster #826

Ceftazidime-avibactam activity against a challenge set of carbapenem-resistant Enterobacterales: Ompk36 L3 alterations and beta-lactamases with ceftazidime hydrolytic activity lead to elevated MIC values. by Castanheira M, Doyle TB, Hubler C, Sader HS and Mendes RE. published in Int. J. Antimicrob. Agents. 2020; 56 (1): 106011, 2020

Omadacycline in vitro activity against a molecularly characterized collection of clinical isolates with known acquired tetracycline resistance mechanisms. by Mendes RE, Huband MD, Streit JM, Castanheira M and Flamm RK. published in Diagn. Microbiol. Infect Dis. 2020; 97 (3):115054.

First report of bla _VIM-4– and mcr-9-coharboring Enterobacter species isolated from a pediatric patient. by Chavda KD, Westblade LF, Satlin MJ, Hemmert AC, Castanheira M, Jenkins SG, Chen L and Kreiswirth BN published in mSphere. 2019; 4 (5): e00629

β-Lactam Resistance Mechanisms in Pseudomonas aeruginosa Isolates Analyzed Using Whole Genome Sequencing (WGS) and Transcriptome Analysis and Their Impact in Resistance to New β-Lactam/β-Lactamase Inhibitors. Lead author: M Castanheira, presented at ID Week 2019, October 2-6, Washington DC, USA
Poster #600

Epidemiologic Analysis of a Worldwide Collection of Escherichia coli ST131 Using the 1928D Core Genome Multilocus Sequence Typing Reveals Country Specific and Globally Disseminated Clades. Lead author: LM Deshpande, presented at ID Week 2019, October 2-6, Washington DC, USA
Poster #239

In vitro Activity of the Orally Bioavailable Ceftibuten/VNRX-7145 Combination against a Challenge Set of Enterobacteriaceae Pathogens Carrying Molecluarly Characterized β-Lactamase Genes. Lead author: RE Mendes, presented at ASM/ESCMID 2019, September 3-6, Boston, MA, USA
Poster #73