Filter by Category: Molecular Studies

Omadacycline in vitro activity against a molecularly characterized collection of clinical isolates with known acquired tetracycline resistance mechanisms.

Omadacycline in vitro activity against a molecularly characterized collection of clinical isolates with known acquired tetracycline resistance mechanisms. by Mendes RE, Huband MD, Streit JM, Castanheira M and Flamm RK. published in Diagn Microbiol Infect Dis. 2020 in press.

First report of bla VIM-4– and mcr-9-coharboring Enterobacter species isolated from a pediatric patient.

First report of bla VIM-4– and mcr-9-coharboring Enterobacter species isolated from a pediatric patient. by Chavda KD, Westblade LF, Satlin MJ, Hemmert AC, Castanheira M, Jenkins SG, Chen L and Kreiswirth BN published in mSphere. 2019; 4 (5): e00629

β-Lactam Resistance Mechanisms in Pseudomonas aeruginosa Isolates Analyzed Using Whole Genome Sequencing (WGS) and Transcriptome Analysis and Their Impact in Resistance to New β-Lactam/β-Lactamase Inhibitors

β-Lactam Resistance Mechanisms in Pseudomonas aeruginosa Isolates Analyzed Using Whole Genome Sequencing (WGS) and Transcriptome Analysis and Their Impact in Resistance to New β-Lactam/β-Lactamase Inhibitors. Lead author: M Castanheira, presented at ID Week 2019, October 2-6, Washington DC, USA
Poster #600

Epidemiologic Analysis of a Worldwide Collection of Escherichia coli ST131 Using the 1928D Core Genome Multilocus Sequence Typing Reveals Country Specific and Globally Disseminated Clades

Epidemiologic Analysis of a Worldwide Collection of Escherichia coli ST131 Using the 1928D Core Genome Multilocus Sequence Typing Reveals Country Specific and Globally Disseminated Clades. Lead author: LM Deshpande, presented at ID Week 2019, October 2-6, Washington DC, USA
Poster #239

In vitro Activity of the Orally Bioavailable Ceftibuten/VNRX-7145 Combination against a Challenge Set of Enterobacteriaceae Pathogens Carrying Molecluarly Characterized β-Lactamase Genes

In vitro Activity of the Orally Bioavailable Ceftibuten/VNRX-7145 Combination against a Challenge Set of Enterobacteriaceae Pathogens Carrying Molecluarly Characterized β-Lactamase Genes. Lead author: RE Mendes, presented at ASM/ESCMID 2019, September 3-6, Boston, MA, USA
Poster #73

Omadacycline Is Not a Substrate for Clinically Relevant β-Lactamase Enzymes

Omadacycline Is Not a Substrate for Clinically Relevant β-Lactamase Enzymes. Lead author: RE Mendes, presented at ASM/ESCMID 2019, September 3-6, Boston, MA, USA
Poster # W-62

Evaluation of the synergy of ceftazidime-avibactam in combination with meropenem, amikacin, aztreonam, colistin and fosfomycin against well characterized multi-drug resistant K. pneumoniae and P. aeruginosa.

Evaluation of the synergy of ceftazidime-avibactam in combination with meropenem, amikacin, aztreonam, colistin and fosfomycin against well characterized multi-drug resistant K. pneumoniae and P. aeruginosa. by Mikhail S, Singh NB, Kebriaei R, Rice SA, Stamper KC, Castanheira M and Rybak MJ. Antimicrob. Agents Chemother. 2019; 63 (8): e00779

Combination of MexAB-OprM overexpression and mutations in efflux regulators, PBPs and chaperone proteins is responsible for ceftazidime/avibactam resistance in Pseudomonas aeruginosa clinical isolates from US hospitals.

Combination of MexAB-OprM overexpression and mutations in efflux regulators, PBPs and chaperone proteins is responsible for ceftazidime/avibactam resistance in Pseudomonas aeruginosa clinical isolates from US hospitals. by Castanheira M, Doyle TB, Smith CJ, Mendes RE and Sader HS. published in J. Antimicrob. Chemother. 2019; 74 (9): 2588-2595

Evaluation of the Staphylococcus aureus Analysis “1928D” Pipeline to Determine the Epidemiological Threshold Using Whole Genome Sequence Data

Evaluation of the Staphylococcus aureus Analysis “1928D” Pipeline to Determine the Epidemiological Threshold Using Whole Genome Sequence Data. Lead author: LM Deshpande, presented at ECCMID 2019, April 13-16, Amsterdam, Netherlands
#P2686

Azole Resistance in Candida parapsilosis and Candida tropicalis from a Global Surveillance is Mainly Caused by Alterations in Erg11 and MDR1 Overexpression

Azole Resistance in Candida parapsilosis and Candida tropicalis from a Global Surveillance is Mainly Caused by Alterations in Erg11 and MDR1 Overexpression. Lead author: M Castanheira, presented at ECCMID 2019, April 13-16, Amsterdam, Netherlands
#P2162